What are reversible and irreversible HDAC inhibitors? How does HDAC inhibitor selectively inhibits the cancer cell and not the normal cell?

Md Ariful Islam

0 like 0 dislike
1 views
Share with your friends

1 Answers

Md Ariful Islam

Call
Epigenic modifications, mainly DNA methylation and acetylation, are recognized as the main mechanisms contributing to the malignant phenotype. Acetylation and deacetylation are catalyzed by specific enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs), respectively. While histones represent a primary target for the physiological function of HDACs, the antitumor effect of HDAC inhibitors might also be attributed to transcription independent mechanisms by modulating the acetylation status of a series of nonhistone proteins. HDAC inhibitors may act through the transcriptional reactivation of dormant tumor suppressor genes. They also modulate expression of several other genes related to cell cycle, apoptosis, and angiogenesis. Several HDAC inhibitors are currently in clinical trials both for solid and hematologic malignancies. Thus, HDAC inhibitors, in combination with DNA-demethylating agents, chemopreventive, or classical chemotherapeutic drugs, could be promising candidates for cancer therapy. Here, we review the molecular mechanisms and therapeutic potential of HDAC inhibitors for the treatment of cancer.
0 like 0 dislike
1 views
Talk Doctor Online in Bissoy App
short notes on these topics about 1 1/2 pages a) Nuclear export of mRNA b) mRNA stability c) Inhibitors of transcription and their mode of action d) Inhibitors of translation and their mode of action

Short NotesNuclear Export of mRNA The expression of eukaryotic genes is controlled by several mechanisms. Its regulation is considered to be critical for physiological responses associated with intracellular and extracellular signals....

1 Answers 1 views
Why are uncompetitive and mixed inhibitors generally considered to be more effective in vivo than competitive inhibitors?

In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time.the substrate and inhibitor compete for access to the enzyme's active site. In vivo, substrate...

1 Answers 1 views
Feedback inhibition involves... a)noncompetitive inhibitors b)competitive inhibitors c)cofactors d)high concentration of substrate e)low concentration of enzyme

Feedback inhibition involves low concentration of enzyme.

1 Answers 1 views
Farmers selectively breed crop plant. Describe the process of selective breeding?

Selective breeding is when you mate specific plants to pass on a certain genetic trait they may have. Farmers use selective breeding to breed the best plants for feeding, selling...

1 Answers 1 views
1. Should the G0 (this is zero subscript) phase be a regular part of the cell cycle? Why or why not? 2. Can restoring the cell cycle checkpoints address cancer?

1. G0 phase is viewed to be a phase where the cell is neither dividing nor preparing to divide, or a distinct quiescent stage that occurs outside of the...

1 Answers 1 views
Task 2. Draw a mitotic cycle, indicate mitogenic stimuli and inhibitors that determine different phases of the cell cycle

Mitogenic stimuli comprise the activated protein kinase. The inhibitors include the mitosis checkpoint kinase, mitosis enzyme inhibitors, microtubin enzyme inhibitors, and microtubin binders.  

1 Answers 1 views
Describe how the antigen presenting cell (APC) pathway can be used to selectively target cancer cells.

The cancer cell generally formed due to some genes regulation problems which leads to cell grow in uncontrolled manner. The cell grow and some cell apoptosis, so the peptides may...

1 Answers 1 views
1)Describe the electrical transport with the irreversible thermodynamic? 2) Describe the ion transport in the lithium-ion-battery with the irreversible thermodynamic

1. Irreversible processes are actual processes carried out in finite time with real substances with internal temperature, pressure, and velocity changes causing energy dissipation, such as viscous dissipation.

1 Answers 1 views
Define and explain the followings: - intensive property - extensive property - isothermal property - isochoric - cyclic process - reversible and irreversible - path process - state

Solution: - Intensive property: It is independent of mass or material present insystem.e.g, temperatureExtensive property: It is dependent of mass or material present in system. e.g, volume.Isothermal property:Iso means same...

1 Answers 1 views
Which enzyme is inhibited by penicillin? Is it reversible inhibitor?

Bacteria constantly rearrange their peptidoglycan cell walls, simultaneously building and destroying parts of the cell wall as they grow and divide. beta-lactam antibiotics inhibit the formation of peptidoglycan cross-links in...

1 Answers 1 views
X