Friedel Craft alkylation (or acylation) is by definition an electrophilic aromatic substitution whereby an alkyl or acyl group is substituted for a hydrogen atom on an aromatic ring. So if...
1 Answers 1 viewsThe bond strength of a $2""^@$ alkyl halide must be comparable to a $1""^@$ alkyl halide. Enthalpy is thus not really a determinant. In terms of kinetics, the $1""^@$ halide...
1 Answers 1 viewsYou could write whole chapters in an organic text to answer this question. And of course what follows is merely a guide to further reading. We know that $S_(N)1$ reactions...$"substitution...
1 Answers 1 viewsIn a $S_n1$ reaction the reaction rate does only depend on the concentration of the substrate. Mening that you can add all the nucleophile you wan't but the reaction wont...
1 Answers 1 views1-more stearic hindrance, more chance to give SN1 Rn. vice versa 2-more hyperconjugation capability of a substrate, more stable will be the carbocation ultimately more chance to give SN1 Rn....
1 Answers 1 viewsWater is a weak nucleophile so it would favor SN1. We know that weak nucleophiles doesn't have any negative charge (i.e. -OH, Iodine).
1 Answers 1 viewsThe clearest difference is in their names! SN1 reactions are unimolecular, stepwise mechanisms, where, $"R" = k["LG"^(-)]$ SN2 reactions are bimolecular, concerted mechanisms, where, $"R" = k["LG"^-]["Nu"]$ These reactions are...
1 Answers 1 viewsNow of course $S_N1$ and $S_N2$ reactions are DISSOCIATIVE (i.e. bond-breaking), and ASSOCIATIVE (bond-making) respectively to a first approximation. Associative mechanisms are largely restricted to methyl, primary, and more rarely,...
1 Answers 1 viewsThe point is that YOU DON'T KNOW. And for this we apply $"a posteriori"$ reasoning, argument AFTER the fact, rather than $"a priori"$ reasoning, argument BEFORE the fact. Mix...
1 Answers 1 viewsFor nucleophilic substitutions, SN1 and SN2 are equally important, however, for the $beta$-elimination, E2 is much more common and useful than E1.
1 Answers 1 views